Angela E. Douglas

Principal Investigator

Department of Entomology|Department of Molecular Biology & Genetics

Phone: 607-255-8539

Email: aes326@cornell.edu

My research interests are symbiosis and nutritional physiology. The three strands to my research are intracellular microbial symbioses in insects; beneficial gut microbes in insects, especially Drosophila; and insect nutrition.

I joined Cornell University in 2008 as the Daljit S. and Elaine Sarkaria Professor of Insect Physiology and Toxicology. Before that, I was a member of faculty at the University of York, UK (1996 senior lecturer, 1999 reader, 2003 professor); a Royal Society University Research Fellow (1986-1996); and I did postdoctoral research at the University of Oxford and University of East Anglia. I obtained a PhD at the University of Aberdeen, UK (1981) and BA (zoology) at the University of Oxford, UK (1978). My CV is available as a a download on the left sidebar of this page.

I am interested in how insects work. My core research area is insect nutritional physiology (how insects process food for growth and reproduction), including the contribution of symbiotic microorganisms to insect nutrition. The three current research foci in the laboratory are: Drosophila-gut microbe interactions. We are investigating the composition of the gut microbiota by molecular and microbiological methods, and how the presence and composition of the microbiota interacts with the nutritional condition and immunological function of the insect.   Our purpose is to use this association, as a general model system for animal-gut microbe interactions. Metabolic coupling in insect-bacterial We are investigating coupled metabolism, i.e. metabolic pathways shared between the animal and microbial partners, and the mechanisms by which they are regulated, using genome mining, metabolic modeling and metabolic analysis.  Our primary focus is essential amino acid synthesis in associations between plant sap feeding insects and their bacterial symbionts.  Sugar relations of plant sap-feeding insects.  We are addressing how the insects process dietary sugars, which are both the dominant carbon source and osmotic challenge for these insects. Our research includes interference with the function of insect sugar processing genes, as a novel control strategy for phloem-feeding insect pests.

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