Soren Franzenburg

Postdoctoral researcher

Email: sfranzenburg [at] cornell.edu

All animals are associated with commensal microbial communities that contribute to the host’s health. Dysregulation of this host-microbial homeostasis was shown to contribute to a broad range of disease phenotypes. I am interested in determining the function of the microbiota and the mechanisms ensuring a homeostatic interaction between the involved organisms. How does the host recognize its microbiota and elicits an adequate response? How does the interaction between the associated partners influence gene expression, allowing us to track the physiological effects of this symbiosis. How does the host-microbial interplay vary between different Drosophila species and do these beneficial interactions impact the host’s ecological phenotype?

I received my biology diploma and my phD at the University of Kiel / Germany, supervised by Professor Thomas Bosch. My work included the investigation of the interplay between the host innate immune system and its associated microbiota. I analyzed the effects of Toll-like receptor signaling and antimicrobial peptides in the freshwater cnidarian Hydra.

Publications

Franzenburg S, Fraune S, Künzel S, Baines JF, Domazet-Loso T, Bosch TC. 2012. MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers. PNAS 109(47):19374-9. doi: 10.1073/pnas.1213110109. Epub 2012 Oct 29.

Franzenburg S, Fraune S, Altrock PM, Künzel S, Baines JF, Traulsen A, Bosch TC. 2013. Bacterial colonization of Hydra hatchlings follows a robust temporal pattern. ISME J. 7 (4):781-90. doi: 10.1038/ismej.2012.156. Epub 2013 Jan 24.